MiRNA-181d Is Involved in CREB1 Expression in PC12 Cells

MicroRNAs are involved in regulation of the central nervous system (CNS) development, and miR-181d highly expressed mature neurons. CREB is many signal pathways converged point hippocampal neurons, it plays a crucial role learning memory. In this study, we detected negative relationship between CREB1 protein expression lewis rat hippocampus development. And bioinformatic analysis showed that, mRNA contains complementary sequence to seed region. Then further demonstrated that controls level gene PC12 cells by luciferase assay western blot. Taken together, our data target miR-181d, conformed was regulated cells.